Identification of new biomarker candidates for glucocorticoid induced insulin resistance using literature mining
نویسندگان
چکیده
منابع مشابه
Biomarker Identification Using Text Mining
Identifying molecular biomarkers has become one of the important tasks for scientists to assess the different phenotypic states of cells or organisms correlated to the genotypes of diseases from large-scale biological data. In this paper, we proposed a text-mining-based method to discover biomarkers from PubMed. First, we construct a database based on a dictionary, and then we used a finite sta...
متن کاملAngiopoietin-like 4 in glucocorticoid induced insulin resistance
Glucocorticoids play a key role in metabolic adaptation during stress. The major metabolic function of glucocorticoids is to preserve plasma the glucose levels that serve as the major energy source for the brain [1]. Therefore, glucocorticoids antagonize the ability of insulin to suppress hepatic gluconeogenesis and promote glucose utilization in white adipose tissue (WAT) and skeletal muscle [...
متن کاملNew mechanisms of glucocorticoid-induced insulin resistance: make no bones about it.
Glucocorticoids are a powerful tool used to treat a range of human illnesses, including autoimmune diseases and cancer, and to prevent rejection following organ transplantation. While lifesaving for many, they come with a steep price, often leading to obesity, insulin resistance, diabetes, and osteoporosis. In this issue of the JCI, Brennan-Speranza and colleagues provide evidence that the oste...
متن کاملEffect of Vanadyl Sulfate on Fructose-Induced Insulin Resistance Rat
Insulin resistance syndrome, also referred to as the metabolic syndrome or syndrome X, refers to a constellation of common metabolic and cardiovascular disorders (e.g. obesity, type 2 diabetes mellitus, hypertension, and dyslipidemia), which are all cardiovascular risk factors. Insulin resistance can be induced by fructose-rich diet in rats. We investigated the effect of vanadyl sulfate (0.2 mg...
متن کاملMining biomarker information in biomedical literature
BACKGROUND For selection and evaluation of potential biomarkers, inclusion of already published information is of utmost importance. In spite of significant advancements in text- and data-mining techniques, the vast knowledge space of biomarkers in biomedical text has remained unexplored. Existing named entity recognition approaches are not sufficiently selective for the retrieval of biomarker ...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: BioData Mining
سال: 2013
ISSN: 1756-0381
DOI: 10.1186/1756-0381-6-2